Lomitapide

Catalog No. A12778

Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor.
  • Julien Allard, .et al. Drug-induced Hepatic Steatosis in Absence of Severe Mitochondrial Dysfunction in HepaRG Cells: Proof of Multiple Mechanism-Based Toxicity, Cell Biol Toxicol, 2020, Jun 14 PMID: 32535746
Catalog Num A12778
M. Wt 692.71
Formula C39H37F6N3O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 182431-12-5
Synonyms 0
SMILES C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor.
Targets
MTP
In vitro DMSO 100 mg/mL (144.36 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL heating (144.36 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.44 mL 72.18 mL 144.36 mL
0.5 mM 2.89 mL 14.44 mL 28.87 mL
1 mM 1.44 mL 7.22 mL 14.44 mL
5 mM 0.29 mL 1.44 mL 2.89 mL

*The above data is based on the productmolecular weight 692.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.