C646Catalog No. A12815

Quick Overview

C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).
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C646

C646  Citations(1)
  • Zhifeng Zhang,et al. XRCC5 cooperates with p300 to promote cyclooxygenase-2 expression and tumor growth in colon cancers, PLoS One, 2017, 12(10): e0186900 29049411
  • Product Information
    Catalog Num A12815
    M. Wt 445.42
    Formula C24H19N3O6
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 328968-36-1
    Synonyms C 646, C-646
    Chemical Name 4-[4-[[5-(4,5-Dimethyl-2-nitropheny?l)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo?-1H-pyrazol-1-yl]benzoic acid
    SMILES Code CC1=C(C=C(C(=C1)C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C)[N+](=O)[O-])C

    Biological activity
    Introduction
    C646 is a selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM).
    Targets
    p300/CBP (Cell-free assay)
    400 nM(Ki)
    Solubility
    Solubility (25C) * In vitro DMSO 13 mg/mL (29.18 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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    High Purity Kinase Inhibitors on Signaling Pathways

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