LGK-974Catalog No. A12816

Quick Overview

LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
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LGK-974

LGK-974  Citations(2)
  • Yang JM, .et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/汕-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152
  • E Lemieux, .et al. Oncogenic KRAS signalling promotes the Wnt/汕-catenin pathway through LRP6 in colorectal cancer, Oncogene, 2015, Sep 17; 34(38): 4914每4927 PMID: 25500543
  • Product Information
    Catalog Num A12816
    M. Wt 396.44
    Formula C23H20N6O
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 1243244-14-5
    Synonyms LGK974, LGK 974
    Chemical Name 2-(2',3-dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide
    SMILES Code

    Biological activity
    Introduction
    LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
    Targets
    Porcn (TM3 cells)
    Solubility
    Solubility (25C)* In vitro DMSO 79 mg/mL heating (199.27 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol <1 mg/mL (<1 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
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    High Purity Kinase Inhibitors on Signaling Pathways

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