Monomethyl auristatin ECatalog No. A12954

Quick Overview

Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
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Monomethyl auristatin E

Monomethyl auristatin E  Citations(1)
  • Sochaj-Gregorczyk AM, .et al. A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines, J Immunother, 2016, Jul-Aug;39(6):223-32 PMID: 27227324
  • Product Information
    Catalog Num A12954
    M. Wt 717.98
    Formula C39H67N5O7
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 474645-27-7
    Synonyms Monomethylauristatin E, MMAE
    Chemical Name N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
    SMILES Code CC[[email protected]](C)[[email protected]@H]([[email protected]@H](CC(=O)N1CCC[[email protected]]1[[email protected]@H]([[email protected]@H](C)C(=O)N[[email protected]](C)[[email protected]](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](C(C)C)NC

    Biological activity
    Introduction
    Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.
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