Batimastat (BB-94)Catalog No. A12985
Quick Overview
Batimastat (BB-94) is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). It is a low-molecular-weight (MW = 478) and peptide-like collagen substrate analogue consisting of a peptide backbone and a hydroxamic acid group which bind to MMPs and the catalytically active zinc atom respectively.
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Product Information
| Catalog Num | A12985 |
|---|---|
| M. Wt | 477.64 |
| Formula | C23H31N3O4S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 130370-60-4 |
| Synonyms | BB 94 |
| Chemical Name | (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(meth?ylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylp?ropyl)-3-[(2-thienylthio)methyl]butanediamide |
| SMILES Code | CC(C)C[[email protected]]([[email protected]](CSC1=CC=CS1)C(=O)NO)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)NC |
Biological activity
Introduction |
Batimastat (BB-94) is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). It is a low-molecular-weight (MW = 478) and peptide-like collagen substrate analogue consisting of a peptide backbone and a hydroxamic acid group which bind to MMPs and the catalytically active zinc atom respectively. | ||||||||||
Targets |
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Solubility
| Solubility (25C) * | In vitro | DMSO | 96 mg/mL (200.98 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 30 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Return Policy | Contact information |
| Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems. >>This offer is only valid for products purchased directly from Adooq and its authorized distributors. >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased. |
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