GNF 5837Catalog No. A13730

Quick Overview

GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
Products are for laboratory research use only. Not for human use. We do not sell to patients.

GNF 5837

GNF 5837  Citations(3)
  • Tanimizu N,et al. Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver, Development, 2018, Apr 25;145(9). pii: dev159095 29615468
  • Shargh VH,et al. Gelatin-albumin hybrid nanoparticles as matrix metalloproteinases-degradable delivery systems for breast cancer therapy, Nanomedicine (Lond), 2017, May;12(9):977-989 28440712
  • Shargh VH,et al. Albumin hybrid nanoparticles loaded with tyrosine kinase A inhibitor GNF-5837 for targeted inhibition of breast cancer cell growth and invasion, Int J Pharm, 2016, Dec 30;515(1-2):527-534 27793712
  • Product Information
    Catalog Num A13730
    M. Wt 535.49
    Formula C28H21F4N5O2
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 1033769-28-6
    Synonyms GNF-5837, GNF5837
    Chemical Name (Z)-1-(3-((3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
    SMILES Code CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4

    Biological activity
    Introduction
    GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
    Targets
    Target Value
    TrkCIC50: 7nM
    TrkBIC50: 9nM
    TrkAIC50: 11nM
    PDGFRβIC50: 0.87μM
    KitIC50: 0.91μM
    JAK2IC50: 2.9μM
    ALKIC50: 3.4μM
    CSF-1RIC50: 4μM
    FLT3IC50: 5.1μM
    RETIC50: 5.3μM
    MetIC50: 5.8μM
    FGFR4IC50: 7μM
    SrcIC50: 7.3μM
    IGF-1RIC50: 7.6μM
    Insulin ReceptorIC50: 8μM
    AblIC50: 8.2μM
    FGFR3IC50: 9.3μM
    Solubility
    Solubility (25C)* In vitro DMSO 100 mg/mL (186.74 mM)
    Water <1 mg/mL (<1 mM)
    Ethanol 9 mg/mL heating (16.8 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Return Policy Contact information
    Adooq Bioscience has Satisfaction Guarantee return policy. You may return/exchange any items within 365 days from the original purchase date if you are not satisfied with your purchase, either for protocol related or product related problems.

    >>This offer is only valid for products purchased directly from Adooq and its authorized distributors.

    >>Prior to returning any items, please contact the Customer Service ([email protected]) to obtain an Return/Exchange Authorization. Items returned without prior authorization may not be accepted. Any items returned to Adooq should be in the original packaging and in the same condition as originally purchased.


    Website: www.adooq.com
    Order: [email protected]
    Phone:
    (866)930-6790 (US & Canada)
    +1-323-389-9269 (Outside of US & CAN)
    Fax:
    (866)333-9607 (US & Canada)
    +1-323-606-8156 (Outside of US & CAN)
    Support:
    [email protected]

    High Purity Kinase Inhibitors on Signaling Pathways

    Copyright© 2006-2017 Adooq BioScience LLC, All Rights Reserved.
    4000 Barranca Parkway, Suite 250, Irvine, CA 92604 USA. Tel: 855-930-6790