TP-434 (Eravacycline)Catalog No. A13887

Quick Overview

TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms including tetracycline-specific efflux and ribosomal-protection.
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TP-434 (Eravacycline)

TP-434 (Eravacycline)  Citations(2)
  • Fan Zhang, .et al. Eravacycline activity against clinical S. aureus isolates from China: in vitro activity, MLST profiles and heteroresistance, BMC Microbiol, 2018, 18: 211 PMID: 30545293
  • Jin-xin Zheng, .et al. Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae, Emerg Microbes Infect, 2018, 7: 139 PMID: 30068997
  • Product Information
    Catalog Num A13887
    M. Wt 558.555
    Formula C27H31FN4O8
    Solubility DMSO
    Purity >98%
    Storage at -20°C 3 years Powder
    CAS No. 1207283-85-9
    Synonyms Eravacycline, TP434, TP 434
    Chemical Name (4S,4aS,5aR,12aS)-4-(Dimethylamino)-7-fluoro-3,10,12,12a-tetrahydroxy-1,11-dioxo-9-[(1-pyrrolidinylacetyl)amino]-1,4,4a,5,5a,6,11,12a-octahydro-2-tetracenecarboxamide
    SMILES Code CN(C)[[email protected]]1[[email protected]@H]2C[[email protected]@H]3CC4=C(C=C(C(=C4C(=C3C(=O)[[email protected]@]2(C(=C(C1=O)C(=O)N)O)O)O)O)NC(=O)CN5CCCC5)F

    Biological activity
    Introduction
    TP-434 is a novel, broad-spectrum fluorocycline antibiotic with activity against bacteria expressing major antibiotic resistance mechanisms including tetracycline-specific efflux and ribosomal-protection.
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