FR 180204

Catalog No. A14119

FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.

Product Citations

Sergey A Dyshlovoy, .et al. Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties, Sci Rep, 2020, Aug 6;10(1):13178 PMID: 32764580
Dyshlovoy SA, .et al. Proteomic-based investigations on the mode of action of the marine anticancer compound rhizochalinin, Proteomics, 2017, Jun;17(11) PMID: 28445005

Technical details

Catalog Num	A14119
M. Wt	327.34
Formula	C18H13N7
Purity	>98%
Storage	at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.	865362-74-9
Synonyms	FR-180204,FR180204
SMILES	C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=CC5=C(NN=C5N=N4)N

Biological Activity

FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.

Targets

ERK2	ERK1
0.14 μM(Ki)	0.31 μM(Ki)

Solubility *

In vitro	DMSO	57 mg/mL (174.13 mM)
	Water	Insoluble
	Ethanol	Warmed: 2 mg/mL (6.1 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.55 mL	152.75 mL	305.49 mL
0.5 mM	6.11 mL	30.55 mL	61.1 mL
1 mM	3.05 mL	15.27 mL	30.55 mL
5 mM	0.61 mL	3.05 mL	6.11 mL

*The above data is based on the productmolecular weight 327.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience