AZD 2932

Catalog No. A14156

AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively.
Catalog Num A14156
M. Wt 447.49
Formula C24H25N5O4
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 883986-34-3
Synonyms AZD-2932,AZD2932
SMILES CC(C)N1C=C(C=N1)NC(=O)CC2=CC=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC
AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively.
Targets
PDGFRβ Flt3 VEGFR-2 c-Kit
4 nM7 nM8 nM9 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.35 mL 111.73 mL 223.47 mL
0.5 mM 4.47 mL 22.35 mL 44.69 mL
1 mM 2.23 mL 11.17 mL 22.35 mL
5 mM 0.45 mL 2.23 mL 4.47 mL

*The above data is based on the productmolecular weight 447.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.