KN-93 Phosphate

Catalog No. A14288

KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.
  • Kazuki Yuasa, .et al. Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy, Sci Rep, 2018, 8: 9037 PMID: 29899565
Catalog Num A14288
M. Wt 599.03
Formula C26H32ClN2O8PS
Purity >98%
Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No. 1188890-41-6
Synonyms KN93, KN 93
SMILES CN(C/C=C/C1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O
KN-93 Phosphate is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities.
Targets
CaMKII
0.37 μM(Ki)
In vitro DMSO 86 mg/mL (143.56 mM)
Water 79 mg/mL (131.88 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.69 mL 83.47 mL 166.94 mL
0.5 mM 3.34 mL 16.69 mL 33.39 mL
1 mM 1.67 mL 8.35 mL 16.69 mL
5 mM 0.33 mL 1.67 mL 3.34 mL

*The above data is based on the productmolecular weight 599.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.