Edoxaban (tosylate Monohydrate)

Catalog No. A14317

Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM
  • Daniël Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343
Catalog Num A14317
M. Wt 738.27
Formula C24H30ClN7O4S.C7H8O3S.H2O
Purity >98%
Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No. 1229194-11-9
Synonyms DU-176b
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)N[[email protected]@H]3C[[email protected]](CC[[email protected]@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C.O
Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM
Targets
Factor Xa Thrombin FIXa
0.561 nM(Ki)6 μM(Ki)41.7 μM(Ki)
In vitro DMSO 89 mg/mL (120.55 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.55 mL 67.73 mL 135.45 mL
0.5 mM 2.71 mL 13.55 mL 27.09 mL
1 mM 1.35 mL 6.77 mL 13.55 mL
5 mM 0.27 mL 1.35 mL 2.71 mL

*The above data is based on the productmolecular weight 738.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.