PX-478 HClCatalog No. A14319

Quick Overview

PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.
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PX-478 HCl

Product Information
Catalog Num A14319
M. Wt 394.12
Formula C13H20Cl4N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 685898-44-6
Synonyms 0
SMILES Code C1=CC(=CC=C1C[[email protected]@H](C(=O)O)N)[N+](CCCl)(CCCl)[O-].Cl.Cl

Biological activity
Introduction
PX-478 is HIF-1alpha inhibitor, is also an orally active small molecule with potential antineoplastic activity. PX-478 has excellent activity against established human tumor xenografts, providing tumor regressions with prolonged growth delays which correlate positively with HIF-1 levels. PX-478 is a highly water soluble molecule, with good i.v., i.p. and p.o. antitumor activity.
Targets
HIF-1α
Solubility
Solubility (25C)* In vitro DMSO 78 mg/mL (197.9 mM)
Water 78 mg/mL (197.9 mM)
Ethanol 78 mg/mL (197.9 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Return Policy Contact information
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High Purity Kinase Inhibitors on Signaling Pathways

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