PI-3065

Catalog No. A14338

PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM
  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Catalog Num A14338
M. Wt 506.64
Formula C27H31FN6OS
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 955977-50-1
Synonyms PI3065, PI 3065
SMILES C1CC1CN2CCN(CC2)CC3=CC4=C(S3)C(=NC(=N4)C5=C(C=CC6=C5C=CN6)F)N7CCOCC7
PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM
Targets
Target Value
p110δIC50: 15nM
p110βIC50: 1078nM
p110αIC50: 2299nM
mTORIC50: 9082nM
DNA-PKIC50: >10000nM
p110γIC50: 27542nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.74 mL 98.69 mL 197.38 mL
0.5 mM 3.95 mL 19.74 mL 39.48 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL

*The above data is based on the productmolecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.