PF-06447475

Catalog No. A15504

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
Catalog Num A15504
M. Wt 305.33
Formula C17H15N5O
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1527473-33-1
Synonyms PF06447475, PF 06447475
SMILES C1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N
PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
Targets
LRRK2 G2019S LRRK2
3nM11nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.75 mL 163.76 mL 327.51 mL
0.5 mM 6.55 mL 32.75 mL 65.5 mL
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL

*The above data is based on the productmolecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.