HIF-2a Translation Inhibitor

Catalog No. A16181

HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).
Catalog Num A16181
M. Wt 287.31
Formula C9H9N3O4S2
Purity >98%
Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No. 882268-69-1
Synonyms
SMILES COC(=O)C1=C(C=CS1)NN=C(C#N)S(=O)(=O)C
HIF-2a translation inhibitor (IC50 value 5 uM); Decreases HIF-2a protein and HIF-2a target gene expression in normoxia and hypoxia independent of HIF-2a mRNA expression or HIF-2a protein stability, and independent of mTOR activity. Moreover, the translation inhibitor 76 enhances binding of IRP1 to the HIF-2a IRE (Iron-Responsive Element).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 34.81 mL 174.03 mL 348.06 mL
0.5 mM 6.96 mL 34.81 mL 69.61 mL
1 mM 3.48 mL 17.4 mL 34.81 mL
5 mM 0.7 mL 3.48 mL 6.96 mL

*The above data is based on the productmolecular weight 287.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.