PROTAC Bcl2 degrader-1

Catalog No. A18355

PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
Catalog Num A18355
M. Wt 941.84
Formula C45H45BrN6O10S
Purity >98%
Storage at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No. 2378801-85-3
Synonyms
SMILES O=C(NCCOCCOCCNC1=CC=CC(C(N2C3CCC(NC3=O)=O)=O)=C1C2=O)CCCCC(NCCN4C(C5=C6C(C4=O)=CC=C(C6=CC=C5)SC7=CC=C(C=C7)Br)=O)=O
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.62 mL 53.09 mL 106.18 mL
0.5 mM 2.12 mL 10.62 mL 21.24 mL
1 mM 1.06 mL 5.31 mL 10.62 mL
5 mM 0.21 mL 1.06 mL 2.12 mL

*The above data is based on the productmolecular weight 941.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.