DCC-2036 (Rebastinib)

Catalog No.: A11200

Bcr-Abl inhibitor

DCC-2036 (Rebastinib)

DCC-2036 (Rebastinib) Chemical Structure

CAS NO. 1020172-07-9

DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$65.00
10 mg
$110.00
50 mg
$260.00
100 mg
$400.00
10mM * 1mL in DMSO
$120.00
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  • Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Biological Activity

DCC-2036 is an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity.

Targets
Target Value
u-Abl1(native)IC50: 0.75nM
Abl1(H396P)IC50: 1.4nM
p-Abl1(native)IC50: 2nM
FLT3IC50: 2nM
p-Abl1(T315I)IC50: 4nM
KDRIC50: 4nM
u-Abl1(T315I)IC50: 5nM
Tie-2IC50: 6nM
LynIC50: 29nM
SrcIC50: 34nM
FGRIC50: 38nM
HckIC50: 40nM
PDGFRαIC50: 70nM
PDGFRβIC50: 113nM
c-KitIC50: 481nM
AuroraAIC50: >5μM
CDK2/CyclinDIC50: >5μM
In vitro (25°C) DMSO 111 mg/mL (200.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol 16 mg/mL (28.9 mM)
In vivo 0.5% CMC/0.25% Tween 80 16 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.06 mL 90.32 mL 180.64 mL
0.5 mM 3.61 mL 18.06 mL 36.13 mL
1 mM 1.81 mL 9.03 mL 18.06 mL
5 mM 0.36 mL 1.81 mL 3.61 mL

*The above data is based on the productmolecular weight 553.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11200
Actions Inhibitor
M. Wt 553.59
Formula C30H28FN7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1020172-07-9
Synonyms DCC2036
SMILES CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=CC(=NC=C3)C(=O)NC)F)C4=CC5=C(C=C4)N=CC=C5

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