Dehydrogenases

Catalog No.Inhibitor Name Dehydrogenase
A10613Mycophenolate Mofetil
***
A12902AGI-5198
**
A11403MK-8245
****
A15892NCT-501
**
A15798SW033291
****
A12997Vidofludimus
*
A12903AGI-6780
***
A11786CPI-613
A10521Leflunomide
A10320Disulfiram
A10949Trilostane
A12899PluriSIn #1 (NSC 14613)
A10070Ammonium Glycyrrhizinate
A11682Gimeracil
A14795Gossypol Acetate
A10353Enoxolone
A10348Emodin

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

19 Item(s)

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  1. MF-438

    Catalog No. A20963
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    SCD1 inhibitor
    MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1. Learn More
  2. CVT-12012

    Catalog No. A21447
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    SCD inhibitor
    CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively. Learn More
  3. A939572

    Catalog No. A13298
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    SCD1 inhibitor
    A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively. Learn More
  4. CAY10566

    Catalog No. A16936
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    SCD1 inhibitor
    CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. Learn More
  5. MK-8245 Trifluoroacetate

    Catalog No. A15170
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    Liver-targeting SCD Inhibitor‎
    MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Learn More
  6. NCT-501

    Catalog No. A15892
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    hALDH1 Inhibitor‎
    NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM. Learn More
  7. AG-120

    Catalog No. A15869
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    Dehydrogenase Inhibitor
    AG-120 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Learn More
  8. Fomepizole

    Catalog No. A16164
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    alcohol dehydrogenase inhibitor
    Fomepizole is an alcohol dehydrogenase inhibitor used for the treatment of ethylene glycol and methanol poisonings in adults. Learn More
  9. CBR 5884

    Catalog No. A16176
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    PHGDH inhibitor
    CBR 5884 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 33 uM. Learn More
  10. AZD4017

    Catalog No. A13542
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    HSD1 inhibitor
    AZD4017 is a potent, selective, and orally bioavailable11b-HSD1 inhibitor (11b-hydroxysteroid dehydrogenase type 1 inhibitor). Learn More
  11. Vidofludimus (4SC-101)

    Catalog No. A12997
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    DHODH inhibitor
    Vidofludimus is a novel orally active and potent DHODH inhibitor. Learn More
  12. MK-8245

    Catalog No. A11403
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    SCD inhibitor
    MK-8245 is a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor. MK-8245 is useful for the Treatment of Diabetes and Dyslipidemia. Learn More
  13. Mycophenolate mofetil (CellCept)

    Catalog No. A10613
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    IMPDH inhibitor
    Mycophenolate mofetil is a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) in purine biosynthesis (specifically guanine synthesis) which is necessary for the growth of T cells and B cells. Learn More
  14. Gossypol

    Catalog No. A10435
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    dehydrogenase inhibitor
    Gossypol is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. Learn More
  15. Leflunomide

    Catalog No. A10521
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    Dehydrogenase inhibitor
    Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs. Leflunomide is used to relieve symptoms caused by rheumatoid arthritis, such as inflammation, swelling, stiffness, and joint pain. Learn More
  16. CPI-613

    Catalog No. A11786
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    Dehydrogenase Inhibitor
    CPI-613 is a racemic mixture of the enantiomers of a synthetic alpha-lipoic lipoic acid analogue with potential chemopreventive and antineoplastic activities. Learn More
  17. Brequinar

    Catalog No. A12442
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    Dihydroorotate Dehydrogenase Inhibitor
    Brequinar is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. Learn More
  18. CGP 3466B maleate

    Catalog No. A12385
    GAPDH inhibitor
    CGP 3466B maleate is an orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Learn More
  19. Ammonium Glycyrrhizinate (AMGZ)

    Catalog No. A10070
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    Dehydrogenase inhibitor
    Mono-ammonium glycyrrhizinate(AMGZ) is a unique product derived from Licorice root and has an extremely sweet taste. Learn More

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