DHFR

Catalog No.Inhibitor Name DHFROther
A10707Pemetrexed
****
TS,GARFT
A15207Pemetrexed Disodium Hydrate
****
TS,GARFT
A10021Methotrexate
A11522Pralatrexate

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Methotrexate (Abitrexate)

    Catalog No. A10021
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    DHFR inhibitor
    Methotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis. Learn More
  2. Pemetrexed (Alimta)

    Catalog No. A10707
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    Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase. Learn More
  3. Aminopterin

    Catalog No. A11787
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    Aminopterin is an antineoplastic drug. It works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Learn More
  4. Pemetrexed disodium

    Catalog No. A12668
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    DHFR inhibitor
    Pemetrexed disodium is a novel antifolate with multiple targets Learn More
  5. Trimetrexate

    Catalog No. A12796
    Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor. Learn More
  6. NSC 131463 (DAMPA)

    Catalog No. A10655
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    DHFR inhibitor
    NSC 131463 is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM. Learn More
  7. Pralatrexate

    Catalog No. A11522
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    DHFR inhibitor
    Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells. Learn More
  8. Pemetrexed disodium hemipenta hydrate

    Catalog No. A15207
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    Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Learn More
  9. Diaveridine

    Catalog No. A17000
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    DHFR inhibitor
    Diaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent. Learn More

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