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| Catalog No. | Inhibitor Name | DHFR | Other |
|---|---|---|---|
| A10707 | Pemetrexed | **** | TS,GARFT |
| A15207 | Pemetrexed Disodium Hydrate | **** | TS,GARFT |
| A10021 | Methotrexate | ||
| A11522 | Pralatrexate |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Methotrexate (Abitrexate)
Catalog No. A10021 DHFR inhibitorMethotrexate is a cytotoxic agent that inhibits thymidylate synthetase and de novo purine synthesis. Learn More -
Pemetrexed disodium (Alimta)
Catalog No. A10707 Pemetrexed disodium is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase. Learn More -
Aminopterin
Catalog No. A11787 Aminopterin is an antineoplastic drug. It works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Learn More -
Pemetrexed
Catalog No. A12668 -
Trimetrexate
Catalog No. A12796 Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor. Learn More -
NSC 131463 (DAMPA)
Catalog No. A10655 DHFR inhibitorNSC 131463 is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM. Learn More -
Pralatrexate
Catalog No. A11522 DHFR inhibitorPralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells. Learn More -
Pemetrexed disodium hemipenta hydrate
Catalog No. A15207 Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Learn More -
Diaveridine
Catalog No. A17000 DHFR inhibitorDiaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent. Learn More -
WR99210
Catalog No. A18837 DHFR inhibitorWR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of <0.075 nM. WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. Learn More
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