Daphnetin

Catalog No.: A10286
EGFR, PKA,PKC inhibitor
Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25 μM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
Grouped product items
Product Name Price Stock Qty
Daphnetin 10mg
$50.00
In stock
Daphnetin 25mg
$100.00
In stock
Daphnetin 50mg
$180.00
In stock
Daphnetin 100mg
$320.00
In stock
Daphnetin 10mM * 1mL in DMSO
$68.00
In stock
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Biological Activity
Discription Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. It inhibits EGFR kinase (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25 μM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.
Targets
Target Value
Product Information
Catalog Num A10286
Formula C9H6O4
Molecular Weight 178.1
CAS Number 486-35-1
SMILES C1=CC(=C(C2=C1C=CC(=O)O2)O)O
Synonyms 7,8-dihydroxycoumarin
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 33 mg/mL (185.24 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 56.15 mL 280.74 mL 561.48 mL
0.5 mM 11.23 mL 56.15 mL 112.3 mL
1 mM 5.61 mL 28.07 mL 56.15 mL
5 mM 1.12 mL 5.61 mL 11.23 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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