SIS3

Catalog No.: A16065
Smad3 inhibitor
SIS3 is a novel specific inhibitor of Smad3. It has effect on transforming growth factor-beta1-induced extracellular matrix expression.
Grouped product items
Product Name Price Stock Qty
SIS3 5mg
$100.00
In stock
SIS3 10mg
$180.00
In stock
SIS3 25mg
$313.00
In stock
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Adooq Products cited in reputable paper
Adooq's SIS3 has been cited by 2 publications
  • Miao Deng, .et al. , ACS Appl Mater Interfaces, 2021, Apr 21;13(15):18033-18046 PMID: 33834754
  • Wei P, .et al. , Cell Death Dis, 2019, Sep 11;10(9):670 PMID: 31511493
  • Biological Activity
    Discription SIS3 is a novel specific inhibitor of Smad3. It has effect on transforming growth factor-beta1-induced extracellular matrix expression.
    Targets
    Target Value
    Product Information
    Catalog Num A16065
    Formula C28H27N3O3.HCl
    Molecular Weight 489.99
    CAS Number 521984-48-5
    SMILES CN1C(C2=CC=CC=C2)=C(C3=C1N=CC=C3)/C([H])=C([H])/C(N4CCC5=CC(OC)=C(OC)C=C5C4)=O.Cl
    Synonyms SIS 3
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 92 mg/mL (187.76 mM)
    Water Insoluble
    Ethanol 23 mg/mL (46.94 mM)
    In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.41 mL 102.04 mL 204.09 mL
    0.5 mM 4.08 mL 20.41 mL 40.82 mL
    1 mM 2.04 mL 10.2 mL 20.41 mL
    5 mM 0.41 mL 2.04 mL 4.08 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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