Quarfloxin (CX-3543)

Catalog No.: A12380
rRNA biogenesis inhibitor
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.
Grouped product items
Product Name Price Stock Qty
Quarfloxin (CX-3543) 5mg
$250.00
In stock
Quarfloxin (CX-3543) 10mg
$450.00
In stock
Quarfloxin (CX-3543) 25mg
$900.00
In stock
Quarfloxin (CX-3543) 50mg
$1,600.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Adooq's Quarfloxin (CX-3543) has been cited by 4 publications
  • Janne J. M. van Schie, .et al. , Nat Commun, 2020, 11: 4287 PMID: 32855419
  • Yue Sheng, .et al. , Blood, 2020, Aug 21 PMID: 32822452
  • Hald øH, .et al. , Oncogene, 2018, Dec 12 PMID: 30542116
  • Louise E. Kerry, .et al. , PLoS Negl Trop Dis, 2017, Mar; 11(3): e0005432 PMID: 28263991
  • Biological Activity
    Discription Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.
    Product Information
    Catalog Num A12380
    Formula C35H33FN6O3
    Molecular Weight 604.67
    CAS Number 865311-47-3
    SMILES CN1CCC[C@H]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O
    Synonyms CX 3543; Quarfloxacin; CX3543; CX-3543
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 18 mg/mL (35.57 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+30% PEG 300+dd H2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 16.54 mL 82.69 mL 165.38 mL
    0.5 mM 3.31 mL 16.54 mL 33.08 mL
    1 mM 1.65 mL 8.27 mL 16.54 mL
    5 mM 0.33 mL 1.65 mL 3.31 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

      V1

      C2

      V2

    • Calculator Reset
    Keywords: buy Quarfloxin (CX-3543) | Quarfloxin (CX-3543) Supplier | purchase Quarfloxin (CX-3543) | Quarfloxin (CX-3543) cost | Quarfloxin (CX-3543) manufacturer | order Quarfloxin (CX-3543) | Quarfloxin (CX-3543) distributor | buy 865311-47-3 | 865311-47-3 Supplier | purchase 865311-47-3 | 865311-47-3 cost | 865311-47-3 manufacturer | order 865311-47-3 | 865311-47-3 distributor