Salubrinal

Catalog No.: A12676

eIF2α dephosphorylation inhibitor

Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).
Grouped product items
Product Name Price Stock Qty
Salubrinal 10mg
$100.00
In stock
Salubrinal 25mg
$200.00
In stock
Salubrinal 50mg
$350.00
In stock
Salubrinal 100mg
$600.00
In stock
Salubrinal 10mM * 1mL in DMSO
$69.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's Salubrinal has been cited by 1 publications
  • Gregory R. Kardos, .et al. , Front Oncol, 2020, 10: 834 PMID: 32637352
  • Biological Activity
    Discription Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).
    Targets
    Target Value
    Product Information
    Catalog Num A12676
    Formula C21H17N4OSCl3
    Molecular Weight 479.81
    CAS Number 405060-95-9
    SMILES C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 86 mg/mL (179.23 mM)
    Water Insoluble
    Ethanol 2 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.84 mL 104.21 mL 208.42 mL
    0.5 mM 4.17 mL 20.84 mL 41.68 mL
    1 mM 2.08 mL 10.42 mL 20.84 mL
    5 mM 0.42 mL 2.08 mL 4.17 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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