JZL184

Catalog No.: A12747
MAGL Inhibitor
JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).
Grouped product items
Product Name Price Stock Qty
JZL184 10mg
$40.00
In stock
JZL184 25mg
$80.00
In stock
JZL184 50mg
$130.00
In stock
JZL184 100mg
$200.00
In stock
JZL184 10mM * 1mL in DMSO
$61.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's JZL184 has been cited by 4 publications
  • Lakhan S Khara, .et al. , J Exp Biol, 2022, May 1;225(9):jeb244146 PMID: 35438163
  • Md Shah Sufian, .et al. , J Exp Biol, 2021, 21 JUNE
  • Toshihiko Tsutsumi, .et al. , Biochim Biophys Acta Mol Cell Biol Lipids, 2020, Sep;1865(9):158761 PMID: 32629025
  • Rea Pihlaja, .et al. , Front Neurosci, 2017, 11: 299 PMID: 28611577
  • Biological Activity
    Discription JZL184 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor. Blocks hydrolysis of the endocannabinoid 2-arachidonyl glycerol (2-AG) in vivo in the mouse brain (IC50 = 8 nM).
    Product Information
    Catalog Num A12747
    Formula C27H24N2O9
    Molecular Weight 520.49
    CAS Number 1101854-58-3
    SMILES C1CN(CCC1C(C2=CC3=C(C=C2)OCO3)(C4=CC5=C(C=C4)OCO5)O)C(=O)OC6=CC=C(C=C6)[N+](=O)[O-]
    Synonyms JZL-184, JZL 184
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 86 mg/mL (165.22 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5%DMSO+40%PEG300+5%Tween80+ddH2O 2.3 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.21 mL 96.06 mL 192.13 mL
    0.5 mM 3.84 mL 19.21 mL 38.43 mL
    1 mM 1.92 mL 9.61 mL 19.21 mL
    5 mM 0.38 mL 1.92 mL 3.84 mL
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