Selinexor (KPT-330)

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
Grouped product items
Product Name Price Stock Qty
Selinexor (KPT-330) 5mg
$60.00
In stock
Selinexor (KPT-330) 10mg
$100.00
In stock
Selinexor (KPT-330) 25mg
$200.00
In stock
Selinexor (KPT-330) 50mg
$350.00
In stock
KPT-330 10mM * 1mL in DMSO
$112.00
In stock
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Adooq Products cited in reputable paper
Adooq's Selinexor (KPT-330) has been cited by 2 publications
  • Youjin Na, .et al. , Oncogene, 2023, Mar;42(13):1038-1047 PMID: 36759572
  • Chie Ishikawa, .et al. , Invest New Drugs, 2022, Aug;40(4):718-727 PMID: 35477814
  • Biological Activity
    Discription KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
    Targets
    Target Value
    Product Information
    Catalog Num A12582
    Formula C17H11F6N7O
    Molecular Weight 443.31
    CAS Number 1393477-72-9
    SMILES C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
    Synonyms KPT330, KPT 330
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 78 mg/mL (175.94 mM)
    Water Insoluble
    Ethanol 36 mg/mL (81.21 mM)
    In vivo 2% DMSO+40%PEG 300+5% Tween80 +ddH2O 3 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.56 mL 112.79 mL 225.58 mL
    0.5 mM 4.51 mL 22.56 mL 45.12 mL
    1 mM 2.26 mL 11.28 mL 22.56 mL
    5 mM 0.45 mL 2.26 mL 4.51 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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