NSC59984

Catalog No.: A13413
P53 Activator
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
Grouped product items
Product Name Price Stock Qty
NSC59984 5mg
$110.00
In stock
NSC59984 10mg
$190.00
In stock
NSC59984 25mg
$400.00
In stock
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Biological Activity
Discription NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
Targets
Target Value
Product Information
Catalog Num A13413
Formula C12H15N3O4
Molecular Weight 265.27
CAS Number 803647-40-7
SMILES CN1CCN(CC1)C(=O)C=CC2=CC=C(O2)[N+](=O)[O-]
Synonyms NSC 59984, NSC-59984
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 48 mg/mL (180.94 mM)
Water Insoluble
Ethanol 48 mg/mL (180.94 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.7 mL 188.49 mL 376.97 mL
0.5 mM 7.54 mL 37.7 mL 75.39 mL
1 mM 3.77 mL 18.85 mL 37.7 mL
5 mM 0.75 mL 3.77 mL 7.54 mL
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