UNC0642

Catalog No.: A15487
G9a/GLP inhibitor
UNC0642 is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 < 2.5 nM). It reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM). Displays modest brain penetration in vivo.
Grouped product items
Product Name Price Stock Qty
UNC0642 10mg
$108.00
In stock
UNC0642 25mg
$216.00
In stock
UNC0642 50mg
$324.00
In stock
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Adooq Products cited in reputable paper
Adooq's UNC0642 has been cited by 1 publications
  • Afifa Yaqub, .et al. , Pakistan Journal of Zoology, 2022, 54(6)
  • Biological Activity
    Discription UNC0642 is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 < 2.5 nM). It reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM). Displays modest brain penetration in vivo.
    Product Information
    Catalog Num A15487
    Formula C29H44F2N6O2
    Molecular Weight 546.69
    CAS Number 1481677-78-4
    SMILES CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F
    Synonyms UNC 0642, UNC-0642
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 88 mg/mL (160.96 mM)
    Water Insoluble
    Ethanol 88 mg/mL (160.96 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.29 mL 91.46 mL 182.92 mL
    0.5 mM 3.66 mL 18.29 mL 36.58 mL
    1 mM 1.83 mL 9.15 mL 18.29 mL
    5 mM 0.37 mL 1.83 mL 3.66 mL
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