GSK-J4
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
Not your Region? View all Distributors
Discription | GSK J4 is a cell permeable prodrug rapidly hydrolyzed by macrophage esterases to GSK-J1, a potent selective jumonji H3K27 demethylase inhibitor; attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNF?? release). |
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Catalog Num | A12732 |
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Formula | C24H27N5O2 |
Molecular Weight | 417.5 |
CAS Number | 1373423-53-0 |
SMILES | CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4 |
Synonyms | GSK J4 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2