Capmatinib (INCB28060)

INCB28060, a novel inhibitor of c-MET kinase. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.
Grouped product items
Product Name Price Stock Qty
Capmatinib (INCB28060) 5mg
$45.00
In stock
Capmatinib (INCB28060) 10mg
$65.00
In stock
Capmatinib (INCB28060) 25mg
$85.00
In stock
Capmatinib (INCB28060) 50mg
$100.00
In stock
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Adooq Products cited in reputable paper
Adooq's Capmatinib (INCB28060) has been cited by 1 publications
  • Geoffrey A Pettitt, .et al. , J Pathol, 2023, Feb;259(2):220-232 PMID: 36385700
  • Biological Activity
    Discription INCB28060, a novel inhibitor of c-MET kinase. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.
    Targets
    Target Value
    Product Information
    Catalog Num A11132
    Formula C23H17FN6O
    Molecular Weight 412.4
    CAS Number 1029712-80-8
    SMILES CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F
    Synonyms INCB-28060, INC-280, INC280
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 2 mg/mL (4.84 mM)
    Water Insoluble
    Ethanol Insoluble
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.25 mL 121.24 mL 242.48 mL
    0.5 mM 4.85 mL 24.25 mL 48.5 mL
    1 mM 2.42 mL 12.12 mL 24.25 mL
    5 mM 0.48 mL 2.42 mL 4.85 mL
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    This equation is commonly abbreviated as: C1V1 = C2V2

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