TH287

Catalog No.: A15536
MTH1 inhibitor
TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16,
Grouped product items
Product Name Price Stock Qty
TH287 10mg
$90.00
In stock
TH287 25mg
$250.00
In stock
TH287 50mg
$480.00
In stock
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Biological Activity
Discription TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16,
Targets
Target Value
Product Information
Catalog Num A15536
Formula C11H10Cl2N4
Molecular Weight 269.13
CAS Number 1609960-30-6
SMILES CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N
Synonyms TH-287, TH 287
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 48 mg/mL (178.35 mM)
Water Insoluble
Ethanol Warmed: 9 mg/mL (33.44 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.16 mL 185.78 mL 371.57 mL
0.5 mM 7.43 mL 37.16 mL 74.31 mL
1 mM 3.72 mL 18.58 mL 37.16 mL
5 mM 0.74 mL 3.72 mL 7.43 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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