PF-5274857

Catalog No.: A12775
Smoothened Inhibitor
PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ?? 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ?? 1.4 nmol/L in cells.
Grouped product items
Product Name Price Stock Qty
PF-5274857 5mg
$81.00
In stock
PF-5274857 10mg
$138.00
In stock
PF-5274857 25mg
$243.00
In stock
PF-5274857 50mg
$405.00
In stock
PF-5274857 10mM * 1mL in DMSO
$251.00
In stock
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Biological Activity
Discription PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ?? 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ?? 1.4 nmol/L in cells.
Targets
Target Value
Product Information
Catalog Num A12775
Formula C20H25ClN4O3S
Molecular Weight 436.96
CAS Number 1373615-35-0
SMILES CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C
Synonyms PF5274857, PF 5274857
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 83 mg/mL (189.95 mM)
Water 83 mg/mL (189.95 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.89 mL 114.43 mL 228.85 mL
0.5 mM 4.58 mL 22.89 mL 45.77 mL
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

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This equation is commonly abbreviated as: C1V1 = C2V2

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