FTI 277

Catalog No.: A12368
FTase inhibitor
FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
Grouped product items
Product Name Price Stock Qty
FTI 277 5mg
$90.00
In stock
FTI 277 10mg
$160.00
In stock
FTI 277 25mg
$300.00
In stock
FTI 277 50mg
$500.00
In stock
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Biological Activity
Discription FTI 276 is an inhibitor that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific actvation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
Product Information
Catalog Num A12368
Formula C22H29N3O3S2.C2HF3O2
Molecular Weight 561.64
CAS Number 170006-73-2, 1217447-06-7
SMILES COC(=O)[C@H](CCSC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O
Synonyms FTI-277,FTI277, FTI-277 trifluoroacetate
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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