JNK-IN-8

Catalog No.: A12749
JNK Inhibitor
JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively
Grouped product items
Product Name Price Stock Qty
JNK-IN-8 5mg
$79.00
In stock
JNK-IN-8 10mg
$134.00
In stock
JNK-IN-8 25mg
$237.00
In stock
JNK-IN-8 50mg
$395.00
In stock
JNK-IN-8 10mM * 1mL in DMSO
$123.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's JNK-IN-8 has been cited by 1 publications
  • Mark P Roberto, .et al. , Immunity, 2021, Aug 10;54(8):1807-1824.e14 PMID: 34380064
  • Biological Activity
    Discription JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively
    Targets
    Target Value
    Product Information
    Catalog Num A12749
    Formula C29H29N7O2
    Molecular Weight 507.59
    CAS Number 1410880-22-6
    SMILES CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)/C=C/CN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 91 mg/mL (179.27 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.7 mL 98.5 mL 197.01 mL
    0.5 mM 3.94 mL 19.7 mL 39.4 mL
    1 mM 1.97 mL 9.85 mL 19.7 mL
    5 mM 0.39 mL 1.97 mL 3.94 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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