MK-5108 (VX-689)

Catalog No.: A11410
Aurora A Kinase inhibitor
MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase.
Grouped product items
Product Name Stock
MK-5108 5mg
MK-5108 10mg
MK-5108 50mg
MK-5108 100mg
MK-5108 (VX-689) 10mM * 1mL in DMSO
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Adooq Products cited in reputable paper
Adooq's MK-5108 (VX-689) has been cited by 1 publications
  • Wei TW, .et al. , Cancer Res, 2017, Jan 15;77(2):494-508 PMID: 28069801
  • Biological Activity
    Discription MK-5108, also known as VX-689, is a competitive inhibitor of the ATP-binding site of aurora A kinase.
    Targets
    Target Value
    Product Information
    Catalog Num A11410
    Formula C22H21ClFN3O3S
    Molecular Weight 461.9
    CAS Number 1010085-13-8
    SMILES C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O
    Synonyms MK5108, VX689
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 81 mg/mL (175.35 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 0.5% methylcellulose+0.2% Tween 80 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.65 mL 108.25 mL 216.5 mL
    0.5 mM 4.33 mL 21.65 mL 43.3 mL
    1 mM 2.16 mL 10.82 mL 21.65 mL
    5 mM 0.43 mL 2.16 mL 4.33 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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