Dorsomorphin 2HCl

Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.
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Product Name Price Stock Qty
Dorsomorphin 2HCl 10mg
$75.00
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Dorsomorphin 2HCl 25mg
$150.00
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Dorsomorphin 2HCl 50mg
$250.00
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Dorsomorphin 2HCl 10mM * 1mL in DMSO
$55.00
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Adooq Products cited in reputable paper
Adooq's Dorsomorphin 2HCl has been cited by 1 publications
  • Kameshima S, .et al. , Apoptosis, 2019, Feb 8 PMID: 30737648
  • Biological Activity
    Discription Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.
    Targets
    Target Value
    Product Information
    Catalog Num A13720
    Formula C24H27Cl2N5O
    Molecular Weight 472.41
    CAS Number 1219168-18-9
    SMILES C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl
    Synonyms Compound C, BML-275, BML275, BML 275
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Insoluble
    Water 87 mg/mL (184.15 mM)
    Ethanol Insoluble
    In vivo PBS 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.17 mL 105.84 mL 211.68 mL
    0.5 mM 4.23 mL 21.17 mL 42.34 mL
    1 mM 2.12 mL 10.58 mL 21.17 mL
    5 mM 0.42 mL 2.12 mL 4.23 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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