SC-514

Catalog No.: A12746
IκB/IKK Inhibitor
SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
Grouped product items
Product Name Price Stock Qty
SC-514 10mg
$40.00
In stock
SC-514 25mg
$80.00
In stock
SC-514 50mg
$130.00
In stock
SC-514 100mg
$200.00
In stock
SC-514 10mM * 1mL in DMSO
$68.00
In stock
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Biological Activity
Discription SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
Targets
Target Value
Product Information
Catalog Num A12746
Formula C9H8N2OS2
Molecular Weight 224.3
CAS Number 354812-17-2
SMILES C1=CSC=C1C2=CC(=C(S2)C(=O)N)N
Synonyms SC514, SC 514
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 41 mg/mL (182.79 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+2% Tween 80+ddH2O 3 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 44.58 mL 222.92 mL 445.83 mL
0.5 mM 8.92 mL 44.58 mL 89.17 mL
1 mM 4.46 mL 22.29 mL 44.58 mL
5 mM 0.89 mL 4.46 mL 8.92 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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