THZ1
Important Notice: For research use only. We do not sell to patients.
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Important Notice: For research use only. We do not sell to patients.
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Discription | THZ1 is a novel selective and potent covalent CDK7 inhibitor with IC50(binding affinity) of 3.2 nM; inhibits Jurkat cell's proliferation with IC50 of 50 nM | ||
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Targets |
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Catalog Num | A14192 |
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Formula | C31H28ClN7O2 |
Molecular Weight | 566.05 |
CAS Number | 1604810-83-4 |
SMILES | CN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl |
Synonyms | THZ-1,THZ 1 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 96 mg/mL (150.24 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5% DMSO+45% PEG 300+ddH2O | 3 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 17.67 mL | 88.33 mL | 176.66 mL |
0.5 mM | 3.53 mL | 17.67 mL | 35.33 mL |
1 mM | 1.77 mL | 8.83 mL | 17.67 mL |
5 mM | 0.35 mL | 1.77 mL | 3.53 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2