GNF 5837

Catalog No.: A13730
TRK inhibitor
GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
Grouped product items
Product Name Price Stock Qty
GNF 5837 10mg
$90.00
In stock
GNF 5837 25mg
$180.00
In stock
GNF 5837 50mg
$270.00
In stock
GNF 5837 100mg
$450.00
In stock
GNF 5837 10mM * 1mL in DMSO
$80.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Adooq's GNF 5837 has been cited by 3 publications
  • Tanimizu N, .et al. , Development, 2018, Apr 25;145(9). pii: dev159095 PMID: 29615468
  • Shargh VH, .et al. , Nanomedicine (Lond), 2017, May;12(9):977-989 PMID: 28440712
  • Shargh VH, .et al. , Int J Pharm, 2016, Dec 30;515(1-2):527-534 PMID: 27793712
  • Biological Activity
    Discription GNF-5837 is a potent, selective, and orally bioavailable pan-TRK inhibitor that inhibited tumor growth in a mouse xenograft model derived from RIE cells expressing both TRKA and NGF.
    Targets
    Target Value
    Product Information
    Catalog Num A13730
    Formula C28H21F4N5O2
    Molecular Weight 535.49
    CAS Number 1033769-28-6
    SMILES CC1=C(C=C(C=C1)NC(=O)NC2=C(C=CC(=C2)C(F)(F)F)F)NC3=CC4=C(C=C3)/C(=C/C5=CC=CN5)/C(=O)N4
    Synonyms GNF-5837, GNF5837
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 92 mg/mL (171.8 mM)
    Water Insoluble
    Ethanol Warmed: 8 mg/mL (14.93 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.67 mL 93.37 mL 186.74 mL
    0.5 mM 3.73 mL 18.67 mL 37.35 mL
    1 mM 1.87 mL 9.34 mL 18.67 mL
    5 mM 0.37 mL 1.87 mL 3.73 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

      V1

      C2

      V2

    • Calculator Reset
    Keywords: buy GNF 5837 | GNF 5837 Supplier | purchase GNF 5837 | GNF 5837 cost | GNF 5837 manufacturer | order GNF 5837 | GNF 5837 distributor | buy 1033769-28-6 | 1033769-28-6 Supplier | purchase 1033769-28-6 | 1033769-28-6 cost | 1033769-28-6 manufacturer | order 1033769-28-6 | 1033769-28-6 distributor