Z-VAD-FMK

On Sale
Catalog No.: A12373
Pan Caspase Inhibitor
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
Grouped product items
Product Name Price Stock Qty
Z-VAD-FMK 1mg
Special Price $28.00 Regular Price $40.00
In stock
Z-VAD-FMK 5mg
Special Price $98.00 Regular Price $120.00
In stock
Z-VAD-FMK 10mg
Special Price $140.00 Regular Price $200.00
In stock
Z-VAD-FMK 25mg
Special Price $245.00 Regular Price $350.00
In stock
Z-VAD-FMK 10mM * 1mL in DMSO
Special Price $170.00 Regular Price $246.00
In stock
Z-VAD-FMK 50mg
$450.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Adooq's Z-VAD-FMK has been cited by 35 publications
  • Chantal-Kristin Wenzel, .et al. , Toxicol In Vitro, 2023, Sep;91:105625 PMID: 37268255
  • Joshua H Choe, .et al. , Cancer Discov, 2023, May 4;13(5):1250-1273 PMID: 37067901
  • Yu-Chih Hsu, .et al. , Int J Med Sci, 2023, 20(4): 444-454 PMID: 37057216
  • Debin Qi, .et al. , Cell Cycle, 2023, Apr;22(7):818-828 PMID: 36482709
  • Ming-Chun Hung, .et al. , Cell Biosci, 2022, 12: 122 PMID: 35918763
  • Kaori Kanemaru, .et al. , Nat Commun, 2022, May 9;13(1):2347 PMID: 35534464
  • Chie Ishikawa, .et al. , Invest New Drugs, 2022, Aug;40(4):718-727 PMID: 35477814
  • Aida Falgas, .et al. , Biomed Pharmacother, 2022, Jun;150:112940 PMID: 35421785
  • Sumire Suzuki, .et al. , Oncol Rep, 2022, Feb;47(2):40 PMID: 34958115
  • Lina Y Abou Zeid, .et al. , Cell Stress Chaperones, 2022, Jan;27(1):11-25 PMID: 34719748
  • Simon Boudreault, .et al. , Viruses, 2022, Dec 3;14(12):2710 PMID: 36560714
  • Kosar Jabbari, .et al. , Cancers (Basel), 2021, Sep 8;13(18):4521 PMID: 34572749
  • Xiaoyue Deng, .et al. , Invest Ophthalmol Vis Sci, 2021, May 3;62(6):1 PMID: 33938913
  • Liqun Zhao, .et al. , Apoptosis, 2021, Apr 27 PMID: 33905036
  • Sofia Giacosa, .et al. , Cancers (Basel), 2021, Feb 2;13(3):576 PMID: 33540838
  • Hannes Schmid, .et al. , Haematologica, 2021, Jan 14 PMID: 33440919
  • Hua Xu, .et al. , Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
  • El-Ashmawy NE, .et al. , Pathol Oncol Res, 2020, Jan 4 PMID: 31902118
  • Schneider D, .et al. , Clin Epigenetics, 2019, Jul 2;11(1):98 PMID: 31266541
  • Fujiki K, .et al. , Cell Death Differ, 2019, Feb 25 PMID: 30804470
  • T Yamamoto, .et al. , Cell Microbiol, 2019, 2019 PMID: 30702185
  • Maeda N, .et al. , J Biol Chem, 2019, Nov 13. pii: jbc.RA119.010379 PMID: 31723031
  • Miyazawa S, .et al. , Breast Cancer, 2019, Oct 17 PMID: 31625014
  • Yeh HT, .et al. , Eur J Pharmacol, 2019, Sep 10;863:172658 PMID: 31518562
  • D. Bosc, .et al. , Sci Rep, 2018, 8: 11653 PMID: 30076329
  • Tsukamoto H, .et al. , J Biol Chem, 2018, Jun 29;293(26):10186-10201 PMID: 29760187
  • Hiroshi Kuribayashi, .et al. , Cell Death Dis, 2018, Sep; 9(9): 891 PMID: 30166529
  • Matsuo J, .et al. , Can J Microbiol, 2018, Oct 18:1-9 PMID: 30336068
  • Orly Ravid, .et al. , Front Cell Neurosci, 2018, 12: 359 PMID: 30459557
  • Im E, .et al. , Life Sci, 2018, Sep 15;209:259-266 PMID: 30107166
  • Szalai P, .et al. , Cell Calcium, 2018, Dec;76:48-61 PMID: 30261424
  • Im E, .et al. , Life Sci, 2018, Jan 1;192:286-292 PMID: 29128513
  • Iriyama N, .et al. , Leuk Lymphoma, 2018, Jun;59(6):1439-1450 PMID: 28918692
  • Birte Plitzko, .et al. , J Biol Chem, 2017, Dec 22; 292(51): 21102-21116 PMID: 29074620
  • Akashi E, .et al. , Oncol Rep, 2017, Jul;38(1):506-514 PMID: 28586026
  • Biological Activity
    Discription Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
    Targets
    Target Value
    Product Information
    Catalog Num A12373
    Formula C22H30FN3O7
    Molecular Weight 467.49
    CAS Number 187389-52-2
    SMILES C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 80 mg/mL (171.12 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+35 %PEG 300+2%Tween 80+ddH2O 5 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.39 mL 106.95 mL 213.91 mL
    0.5 mM 4.28 mL 21.39 mL 42.78 mL
    1 mM 2.14 mL 10.7 mL 21.39 mL
    5 mM 0.43 mL 2.14 mL 4.28 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

      V1

      C2

      V2

    • Calculator Reset
    Keywords: buy Z-VAD-FMK | Z-VAD-FMK Supplier | purchase Z-VAD-FMK | Z-VAD-FMK cost | Z-VAD-FMK manufacturer | order Z-VAD-FMK | Z-VAD-FMK distributor | buy 187389-52-2 | 187389-52-2 Supplier | purchase 187389-52-2 | 187389-52-2 cost | 187389-52-2 manufacturer | order 187389-52-2 | 187389-52-2 distributor