Obatoclax mesylate (GX15-070)

Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).
Grouped product items
Product Name Price Stock Qty
Obatoclax mesylate 5mg
$50.00
In stock
Obatoclax mesylate 10mg
$80.00
In stock
Obatoclax mesylate 25mg
$160.00
In stock
Obatoclax mesylate 50mg
$240.00
In stock
Obatoclax mesylate 10mM * 1mL in DMSO
$50.00
In stock
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Adooq Products cited in reputable paper
Adooq's Obatoclax mesylate (GX15-070) has been cited by 4 publications
  • Ashlyn Parkhurst, .et al. , Cell Death Dis, 2022, Apr 28;13(4):410 PMID: 35484114
  • Silva S, .et al. , Sci Rep, 2019, Nov 27;9(1):17703 PMID: 31776405
  • Chi-Hung R. Or, .et al. , Int J Mol Sci, 2016, Jan; 18(1): 44 PMID: 28035994
  • P Geserick, .et al. , Cell Death Dis., 2014, 5(9): e1412 PMID: 25210795
  • Biological Activity
    Discription Bcl-2 homology domain-3 (BH3) mimetic,antagonize all antiapoptotic Bcl-2 family proteins (average IC50, 3 umol/L), including Mcl-1 (IC50, 2.9 umol/L) and Bfl-1 (IC50, 5 umol/L).
    Targets
    Target Value
    Product Information
    Catalog Num A10665
    Formula C20H19N3O.CH4O3S
    Molecular Weight 413.5
    CAS Number 803712-79-0
    SMILES CC1=CC(=C(N1)/C=C/2\C(=C/C(=C\3/C=C4C=CC=CC4=N3)/N2)OC)C.CS(=O)(=O)O
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 81 mg/mL (195.89 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.18 mL 120.92 mL 241.84 mL
    0.5 mM 4.84 mL 24.18 mL 48.37 mL
    1 mM 2.42 mL 12.09 mL 24.18 mL
    5 mM 0.48 mL 2.42 mL 4.84 mL
    Useful Calculator

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