AZD8186

Catalog No.: A15759
PI3K inhibitor
AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).
Grouped product items
Product Name Price Stock Qty
AZD8186 10mg
$110.00
In stock
AZD8186 25mg
$300.00
In stock
AZD8186 50mg
$350.00
In stock
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Biological Activity
Discription AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3Kβ (IC50=4 nM) and PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM).
Targets
Target Value
Product Information
Catalog Num A15759
Formula C24H25F2N3O4
Molecular Weight 457.47
CAS Number 1627494-13-6
SMILES CC(C1=C2C(=CC(=C1)C(=O)N(C)C)C(=O)C=C(O2)N3CCOCC3)NC4=CC(=CC(=C4)F)F
Synonyms AZD 8186, AZD-8186
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO Warmed: 82 mg/mL (179.25 mM)
Water Insoluble
Ethanol Warmed: 32 mg/mL (69.94 mM)
In vivo 10% DMSO + 60% TEG+ 30% WFI 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.86 mL 109.3 mL 218.59 mL
0.5 mM 4.37 mL 21.86 mL 43.72 mL
1 mM 2.19 mL 10.93 mL 21.86 mL
5 mM 0.44 mL 2.19 mL 4.37 mL
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This equation is commonly abbreviated as: C1V1 = C2V2

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