ASP8273 (Naquotinib)

Catalog No.: A14408
irreversible EGFR inhibitor
ASP8273 is an orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity.
Grouped product items
Product Name Price Stock Qty
ASP8273 2mg
$80.00
In stock
ASP8273 5mg
$135.00
In stock
ASP8273 10mg
$225.00
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Biological Activity
Discription ASP8273 is an orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity.
Targets
Target Value
Product Information
Catalog Num A14408
Formula C30H42N8O3
Molecular Weight 562.72
CAS Number 1448232-80-1
SMILES O=C(C1=NC(CC)=C(O[C@H]2CN(C(C=C)=O)CC2)N=C1NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)N
Synonyms Naquotinib (free base)
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO Warmed: 50 mg/mL (88.85 mM)
Water Insoluble
Ethanol Warmed: 96 mg/mL (170.6 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.77 mL 88.85 mL 177.71 mL
0.5 mM 3.55 mL 17.77 mL 35.54 mL
1 mM 1.78 mL 8.89 mL 17.77 mL
5 mM 0.36 mL 1.78 mL 3.55 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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