AST 487

Catalog No.: A15003
RET kinase inhibitor
AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret.
Grouped product items
Product Name Price Stock Qty
AST 487 5mg
$220.00
In stock
AST 487 10mg
$400.00
In stock
AST 487 50mg
$820.00
In stock
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Biological Activity
Discription AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret.
Product Information
Catalog Num A15003
Formula C26H30F3N7O2
Molecular Weight 529.56
CAS Number 630124-46-8
SMILES CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC)C(F)(F)F
Synonyms NVP-AST 487
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 89 mg/mL (168.06 mM)
Water Insoluble
Ethanol 29 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.88 mL 94.42 mL 188.84 mL
0.5 mM 3.78 mL 18.88 mL 37.77 mL
1 mM 1.89 mL 9.44 mL 18.88 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

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This equation is commonly abbreviated as: C1V1 = C2V2

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