E-7050 (Golvatinib)

Catalog No.: A11396

c-Met/VEGFR-2 inhibitor

E7050 (also known as golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity.
Grouped product items
Product Name Price Stock Qty
E-7050 (Golvatinib) 10mg
$110.00
In stock
E-7050 (Golvatinib) 25mg
$220.00
In stock
E-7050 (Golvatinib) 50mg
$380.00
In stock
E-7050 (Golvatinib) 100mg
$680.00
In stock
E-7050 (Golvatinib) 10mM * 1mL in DMSO
$129.00
In stock
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Biological Activity
Discription E7050 (also known as golvatinib is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity.
Targets
Target Value
Product Information
Catalog Num A11396
Formula C33H37F2N7O4
Molecular Weight 633.69
CAS Number 928037-13-2
SMILES CN1CCN(CC1)C2CCN(CC2)C(=O)NC3=NC=CC(=C3)OC4=CC(=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 18 mg/mL (28.4 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.78 mL 78.9 mL 157.81 mL
0.5 mM 3.16 mL 15.78 mL 31.56 mL
1 mM 1.58 mL 7.89 mL 15.78 mL
5 mM 0.32 mL 1.58 mL 3.16 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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