Filgotinib

Catalog No.: A14232
JAK inhibitor
Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Grouped product items
Product Name Price Stock Qty
Filgotinib 10mg
$110.00
In stock
Filgotinib 25mg
$180.00
In stock
Filgotinib 50mg
$280.00
In stock
Filgotinib 10mM * 1mL in DMSO
$75.00
In stock
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Biological Activity
Discription Filgotinib is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
Targets
Target Value
Product Information
Catalog Num A14232
Formula C21H23N5O3S
Molecular Weight 425.5
CAS Number 1206161-97-8
SMILES C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5
Synonyms GLPG0634
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 75 mg/mL (176.26 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+ddH2O 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.5 mL 117.51 mL 235.02 mL
0.5 mM 4.7 mL 23.5 mL 47 mL
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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    C2

    V2

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