WYE-125132 (WYE-132)

Catalog No.: A11038
mTOR Inhibitor
WYE-125132 is an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 (IC50 = 0.19 nM; >5,000-fold selective versus PI3Ks).
Grouped product items
Product Name Price Stock Qty
WYE-125132 5mg
$120.00
In stock
WYE-125132 10mg
$200.00
In stock
WYE-125132 50mg
$720.00
In stock
WYE-125132 100mg
$1,200.00
In stock
WYE-125132 (WYE-132) 10mM * 1mL in DMSO
$135.00
In stock
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Biological Activity
Discription WYE-125132 is an ATP-competitive and specific inhibitor of mTORC1 and mTORC2 (IC50 = 0.19 nM; >5,000-fold selective versus PI3Ks).
Targets
Target Value
Product Information
Catalog Num A11038
Formula C27H33N7O4
Molecular Weight 519.6
CAS Number 1144068-46-1
SMILES CNC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCC5(CC4)OCCO5)C(=N2)N6CC7CCC(C6)O7
Synonyms WYE125132, WYE-132, WYE132
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 95 mg/mL (182.83 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.25 mL 96.23 mL 192.46 mL
0.5 mM 3.85 mL 19.25 mL 38.49 mL
1 mM 1.92 mL 9.62 mL 19.25 mL
5 mM 0.38 mL 1.92 mL 3.85 mL
Useful Calculator

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