RITA (NSC 652287)

RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
Grouped product items
Product Name Price Stock Qty
RITA 5mg
$70.00
In stock
RITA 10mg
$120.00
In stock
RITA 25mg
$240.00
In stock
RITA 50mg
$400.00
In stock
RITA (NSC 652287) 10mM * 1mL in DMSO
$100.00
In stock
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Adooq Products cited in reputable paper
Adooq's RITA (NSC 652287) has been cited by 1 publications
  • M Kobayashi, .et al. , Oncotarget, 2020, May 5;11(18):1653-1665 PMID: 32405340
  • Biological Activity
    Discription RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
    Targets
    Target Value
    Product Information
    Catalog Num A11931
    Formula C14H12O3S2
    Molecular Weight 292.4
    CAS Number 213261-59-7
    SMILES C1=C(SC(=C1)C2=CC=C(O2)C3=CC=C(S3)CO)CO
    Synonyms NSC652287, p53 Activator III
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 56 mg/mL (191.53 mM)
    Water Insoluble
    Ethanol 8 mg/mL (27.36 mM)
    In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 34.2 mL 171 mL 342 mL
    0.5 mM 6.84 mL 34.2 mL 68.4 mL
    1 mM 3.42 mL 17.1 mL 34.2 mL
    5 mM 0.68 mL 3.42 mL 6.84 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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