AZ5104

Catalog No.: A15516
EGFR inhibitor
AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Grouped product items
Product Name Price Stock Qty
AZ5104 10mg
$80.00
In stock
AZ5104 25mg
$160.00
In stock
AZ5104 50mg
$278.00
In stock
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Biological Activity
Discription AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
Targets
Target Value
Product Information
Catalog Num A15516
Formula C27H31N7O2
Molecular Weight 485.58
CAS Number 1421373-98-9
SMILES CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC
Synonyms AZ-5104, AZ 5104
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 90 mg/mL (185.34 mM)
Water Insoluble
Ethanol Warmed: 21 mg/mL (43.24 mM)
In vivo 1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.59 mL 102.97 mL 205.94 mL
0.5 mM 4.12 mL 20.59 mL 41.19 mL
1 mM 2.06 mL 10.3 mL 20.59 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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