IQ 3

Catalog No.: A16036
JNK3 inhibitor
IQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-kB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.
Grouped product items
Product Name Price Stock Qty
IQ 3 5mg
$90.00
In stock
IQ 3 10mg
$160.00
In stock
IQ 3 50mg
$520.00
In stock
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Biological Activity
Discription IQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-kB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.
Targets
Target Value
Product Information
Catalog Num A16036
Formula C20H11N3O3
Molecular Weight 341.32
CAS Number 312538-03-7
SMILES C1=CC=C2C(=C1)C3=NC4=CC=CC=C4N=C3C2=NOC(=O)C5=CC=CO5
Synonyms IQ3, IQ-3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 9 mg/mL (26.36 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.3 mL 146.49 mL 292.98 mL
0.5 mM 5.86 mL 29.3 mL 58.6 mL
1 mM 2.93 mL 14.65 mL 29.3 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
Useful Calculator

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