ENMD-2076

Catalog No.: A10352
Aurora A / FLT3 Inhibitor
ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.
Grouped product items
Product Name Price Stock Qty
ENMD-2076 5mg
$80.00
In stock
ENMD-2076 10mg
$140.00
In stock
ENMD-2076 50mg
$400.00
In stock
ENMD-2076 100mg
$650.00
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Biological Activity
Discription ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.
Targets
Target Value
Product Information
Catalog Num A10352
Formula C21H25N7
Molecular Weight 375.5
CAS Number 934353-76-1, 1291074-87-7
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)/C=C/C4=CC=CC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 101 mg/mL (268.99 mM)
Water 1 mg/mL (2.66 mM)
Ethanol Insoluble
In vivo 0.5% CMC+0.25% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.63 mL 133.16 mL 266.31 mL
0.5 mM 5.33 mL 26.63 mL 53.26 mL
1 mM 2.66 mL 13.32 mL 26.63 mL
5 mM 0.53 mL 2.66 mL 5.33 mL
Useful Calculator

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Please check COA/MSDS for correct molecular weight.

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